Synthesis of Thioridazine

Thioridazine hydrochloride is water soluble phenothiazine antipsychotic drug. It's Molecular weight is 407 g/mol, physical appearance is pale yellow solid and melting point is 158-160°C.
IUPAC nome of Thioridazine is 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine.hydrochloride

Synthesis of Thioridazine

Synthesis of thioridazine takes place in two steps. In the first step, 2-methylthiophenothiazine is prepared by the interaction of 2-chlorophenothiazine with methyl thiosodium. In the second step, 2-methylthiophenothiazine is condensed with 2-(1-methyl-1-piperidyl)ethyl chloride to give the official product thioridazine.

Mechanism of Action of Thioridazine

1. Thioridazine blocks postsynaptic dopaminergic D1 and D2 receptors in brain
2. Thioridazine also blocks α-adrenergic effects
3. Depresses the release of hypothalamic and hypophyseal hormones
4. Depresses the reticular activating system
5. Due to these, basal metabolism, temperature, wakefulness, vasomotor tone and emesis of the body is affected

Therapeutic Uses of Thioridazine

1. Treatment of schizophrenia
2. Reducing nervousness
3. Reducing aggression
4. Reducing negative thoughts
5. Reducing hallucinations