Synthesis of Melphalan
IUPAC Name
4-[bis(2-Chloroethyl)amino]-L-phenylalanineBiosynthesis of Melphalan
L-N-Phthalimido-paminophenylalanine ethyl ester when reacted with ethylene oxide yields an intermediate which on treatment with phosphorus oxychloride gives rise to 4-bis-(2-chloroethyl)-amino-L-phenylalanine ethyl ester. This on hydrolysis with HCl yield Melphalan.Therapeutic Uses of Melphalan
Melphalan can be used in the treatment of following diseases-Breast cancer
Neuroblastoma
Ovarian cancer
Rhabdomyosarcoma
Multiple myeloma