Darzens Reaction

Darzens Reaction

Darzens Reaction


Darzens reaction (also known as the Darzens condensation or glycidic ester condensation) is the chemical reaction of a carbonyl compounds (ketone or aldehyde) with an α-haloester to form α,β-epoxy esters.
Darzens Reaction

Mechanism of Darzens Reaction

Stereochemistry of Darzens Reaction depending on the specific structures involved, the epoxide may exist in cis- and trans- forms. A specific reaction may give only cis-, only trans-, or a mixture of the two. The specific stereochemical outcome of the reaction is affected by several aspects of the intermediate steps. Before SN2 reaction is controlled by Kinetics while after SN2 reaction is controlled by Thermodynamics.
Mechanism of  Darzens Reaction

Applications of Darzens Reaction

Applications of Darzens Reaction