Darzens Reaction
Darzens Reaction
Darzens reaction (also known as the Darzens condensation or glycidic ester condensation) is the chemical reaction of a carbonyl compounds (ketone or aldehyde) with an α-haloester to form α,β-epoxy esters.
Mechanism of Darzens Reaction
Stereochemistry of Darzens Reaction depending on the specific structures involved, the epoxide may exist in cis- and trans- forms. A specific reaction may give only cis-, only trans-, or a mixture of the two. The specific stereochemical outcome of the reaction is affected by several aspects of the intermediate steps. Before SN
2 reaction is controlled by Kinetics while after SN
2 reaction is controlled by Thermodynamics.
Applications of Darzens Reaction