The Backbone of Nucleic Acids is Made-Up of

RPSE Asssistant Professor 2025

The backbone of nucleic acids is made-up of:

• (A) Sugar-phosphate linkage
• (B) Sugar-sugar linkage
• (C) Base-base linkage
• (D) Sugar-base linkage

Correct Answer: (A) Sugar-phosphate linkage

The structural framework of DNA and RNA consists of alternating sugar (deoxyribose or ribose) and phosphate groups. This is often referred to as the sugar-phosphate backbone, where nucleotides are joined by 3',5'-phosphodiester bonds.