Chemistry of Cacodyl Oxide

Chemistry of Cacodyl Oxide

Cacodyl Oxide: [(CH3)2As]2O

Cacodyl oxide is an organoarsenic compound historically significant as a major component of "Cadet’s Fuming Liquid". Discovered in 1760, it represents the birth of organometallic chemistry.

1. General Properties

Property Description
IUPAC Name Dimethylarsinous anhydride
Molecular Formula C4H12As2O
Appearance Oily, reddish-brown liquid (impure) or colorless (pure)
Odor Repulsive, intense garlic-like smell
Hazard Extremely toxic and potentially pyrophoric in air

2. Synthesis

A. Historical Synthesis (Cadet's Method)

Originally prepared by heating potassium acetate with arsenic trioxide. This dry distillation produces a mixture of cacodyl and cacodyl oxide.

4 CH3COOK + As2O3 → [(CH3)2As]2O + 2 K2CO3 + 2 CO2

B. Modern Synthesis

It can be prepared in the laboratory by the hydrolysis of dimethylarsinous chloride:

2 (CH3)2AsCl + H2O → [(CH3)2As]2O + 2 HCl

3. Chemical Structure & Bonding

The molecule consists of two dimethylarsenic (CH3)2As units bridged by a single oxygen atom. The arsenic atoms are in the +3 oxidation state. It is structurally similar to an organic ether but with arsenic atoms replacing the carbons adjacent to the oxygen.

Cacodyl Oxide Structure

4. Key Chemical Reactions

  • Oxidation: Upon exposure to air, it can spontaneously ignite or slowly oxidize to cacodylic acid (dimethylarsinic acid).
  • Reaction with Halogen Acids: It reacts with HCl or HI to form the corresponding dimethylarsenic halides.
    [(CH3)2As]2O + 2 HCl → 2 (CH3)2AsCl + H2O
  • Reduction: Further reduction of cacodyl oxide leads to the formation of Cacodyl (tetramethyldiarsane), which contains a direct As—As bond.
Safety Note: Cacodyl oxide and its derivatives are highly toxic and should only be handled in a professional laboratory environment with specialized equipment.

AP Assistant Professor Exam 2020

The first organometallic of main group element was

A. Uranocene
B. Wilkinson Catalyst
C. Zeise's Salt
D. Cacodyl Oxide


Answer: D. Cacodyl Oxide [(CH3)2As]2O

What is the oxidation state of Arsenic in Cacodyl Oxide, [(CH3)2As]2O?

A. +1
B. +3
C. 0
D. +5


Answer: B. +3
In this trivalent state, arsenic forms bonds with two methyl groups and one bridging oxygen atom.

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