Appel Reaction

Appel Reaction

Appel Reaction

Appel reaction converts an alcohol into an alkyl halide using triphenylphosphine and carbon tetrahalide under mild condition. Substitution of OH by halogens follows SN2 process that means it involves the inversion of stereochemistry. Apple reaction is somewhat similar to the Mitsunobu Reaction. Appel Reaction
Appel Reaction

Appel reaction is also effective on carboxylic acids. It is used to convert acid to oxazolines, oxazines and thiazolines.
Appel Reaction

Mechanism of Appel Reaction

The possible mechanism is given below-
Mechanism of Appel Reaction

Applications of Appel Reaction

Applications of Appel Reaction