Mitsunobu Reaction

Mitsunobu Reaction

Mitsunobu Reaction


Mitsunobu reaction transforms primary or secondary alcohol into thioethers, phenyl ethers, esters, and various other compounds using an azodicarboxylate such as diethyl azodicarboxylate (DEAD) or diisopropyl azodicarboxylate (DIAD) and triphenylphosphine via SN2 process(i.e. Inversion of configuration).
Mitsunobu Reaction

Mechanism of Mitsunobu Reaction

The possible mechanism is given below-
Mechanism of Mitsunobu Reaction

Applications of Mitsunobu Reaction

Applications of Mitsunobu Reaction