Mitsunobu Reaction

Mitsunobu reaction transforms primary or secondary alcohol into thioethers, phenyl ethers, esters, and various other compounds using an azodicarboxylate such as diethyl azodicarboxylate (DEAD) or diisopropyl azodicarboxylate (DIAD) and triphenylphosphine via SN₂ process(i.e. Inversion of configuration).

Mechanism of Mitsunobu Reaction

The possible mechanism is given below-

Applications of Mitsunobu Reaction