Nazarov Cyclization | Nazarov Reaction

Nazarov Cyclization

Nazarov Cyclization


Nazarov Cyclization or Reaction is used in the synthesis of cyclopentenones from divinyl ketones using a stoichiometric Lewis acid or protic acid promoter.
 Nazarov Cyclization
Nazarov Cyclization with more substituted substrate generates the product having the double bond with highest degree of substitution.
 Nazarov Cyclization

Mechanism of Nazarov Cyclization

The possible mechanism is given below-
Mechanism of   Nazarov Cyclization

Applications of Nazarov Cyclization

Applications of   Nazarov Cyclization