Diborane Reagent

Diborane Reagent

Diborane Reagent

Preparation of Diborane

Laboratory Method
Boron trichloride reacts with lithium aluminium hydride or boron trifluoride ether solution reacts with sodium borohydride gives diborane.
4BCl3 + 3LiAlH4 → 2B2H6 + 3LiAlCl4
4BF3 + 3NaBH4 → 2B2H6 + 3NaBF4

Applications of Diborane Reagent

Borane is generally used for the reduction of carboxylic acids in the presence of esters, lactones, amides, halides and other functional groups. In addition, borane rapidly reduces aldehydes, ketones and alkenes.

Reduction of Acids, Amides and Nitriles

Diborane is one of the best reagent for the reduction of Acids, Amides and Nitriles.
Applications of  Diborane Reagent

Reactions with Aldehydes and Ketones

Aldehydes and Ketones are reduced to alcohols with diborane.
Applications of  Gilman Reagent

Reactions with Lactones

Lactones are reduced to diol with diborane.
Applications of  Diborane Reagent, Reduction of lactone

Reactions of Alkylboranes

The transformation of alkenes to alcohols proceeds with retention of configuration at the boron bearing carbon.
Applications of  Diborane Reagent, Alkylboranes

Hydroboration of Alkenes and Alkynes

Boranes react with alkenes to form alkylboranes that could be oxidized in the presence of alkaline hydrogenperoxide to give alcohols.
, hydroboration of alkene, Applications of  Diborane Reagent

Alkynes gives aldehyde with diborane.
, hydroboration of alkyne, Applications of  Diborane Reagent


Alkylboranes on treatment with basic silver nitrate lead to coupling of the alkyl groups.
Applications of  Diborane Reagent, Coupling Reaction

Examples of Diborane Reagent

Examples of  Diborane Reagent