Corey-House Reaction
Corey-House Reaction is also called as 'coupling of alkyl halides with organo metallic compounds'. It is a better method than Wurtz reaction because in this method, alkanes with odd number of carbon atoms can also be prepared. An alkyl halides and a lithium dialkyl cuprate (i.e. Gilman Reagent) are reacted to give a higher hydrocarbon.
R-X + R'2CuLi → R-R' + R'Cu + LiX
It is important to note that for this reaction to work successfully, the alkyl halide must be a methyl halide, benzyl halide, primary alkyl halide or a secondary cyclo alkyl halide.
R-X + R'2CuLi → R-R' + R'Cu + LiX
It is important to note that for this reaction to work successfully, the alkyl halide must be a methyl halide, benzyl halide, primary alkyl halide or a secondary cyclo alkyl halide.
