Bischler–Napieralski Reaction

Bischler–Napieralski Reaction

Bischler–Napieralski Reaction or Bischler-Napieralski Cyclization


Bischler–Napieralski reaction is an intramolecular electrophilic aromatic substitution reaction that allows for the cyclization of β-arylethylamides or β-arylethylcarbamates. The β-arylethylamides or β-arylethylcarbamates on heating with a dehydrating agent such as P2O5, POCl3 or ZnCl2 in an inert solvent, results in the formation of 3,4-dihydroisoquinoline derivatives which is dehydrogenated with sulphur or selenium or Pd-C to yield isoquinoline derivative.
Bischler–Napieralski Reaction

Mechanism of Bischler–Napieralski Reaction


Mechanism of  Bischler–Napieralski Reaction

Examples of Bischler–Napieralski Reaction

Applications of Bischler–Napieralski Reaction

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B.Sc. Chemistry
2nd and 4th Semester

Crash Course

NIOS Sr. Secondary Exam April 2025


IIT-JEE(Main) Exam April 2025


NEET(UG) Exam 2025


ORGANIC CHEMISTRY
Special Batch for NEET and IIT-JEE


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Online Class: 20 February 2025