Bischler–Napieralski Reaction or Bischler-Napieralski Cyclization
Bischler–Napieralski reaction is an intramolecular electrophilic aromatic substitution reaction that allows for the cyclization of β-arylethylamides or β-arylethylcarbamates. The β-arylethylamides or β-arylethylcarbamates on heating with a
dehydrating agent such as P2O5, POCl3 or ZnCl2 in an inert solvent, results in the formation of 3,4-dihydroisoquinoline derivatives which is dehydrogenated with sulphur or selenium or Pd-C to yield isoquinoline derivative.
