Active Methylene Compounds Active Methylene Compounds Active methylene compounds are those in which a methylene group (-CH2-) is sandwiched between two strong electron-withdrawing groups. The hydrogen atoms of such a methylene group are highly acidic. Keto Enol Tautomerism Synthesis of Ethyl Acetoacetate Reactions of Ethyl Acetoacetate Synthetic Uses of Ethyl Acetoacetate Synthesis of Diethyl Malonate Reactions of Diethyl Malonate Synthetic Usess of Diethyl Malonate