Lipinski's Rule of 5 Calculator

Lipinski's Rule of 5 Calculator

Evaluate the drug-likeness of a chemical compound based on its physical properties.

Must read Lipinski's Rule of Five

Compound Properties

Molecular Weight (g/mol)

Octanol-Water Partition Coeff (LogP)

Hydrogen Bond Donors (HBD)

Hydrogen Bond Acceptors (HBA)

Analysis Results

Molecular Weight Threshold: ≤ 500 Da

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Partition Coefficient (LogP) Threshold: ≤ 5

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H-Bond Donors Threshold: ≤ 5

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H-Bond Acceptors Threshold: ≤ 10

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* Lipinski's Rule of 5 states that poor absorption/permeability is more likely when there are more than 1 violations of these thresholds.